OTO –Ototoxicant. Quantity Value Units Method Reference Comment; Δ f H° gas: 50. Aspiration hazard. 13 to 297. Mass Spectrom. Environmental Protection Agency priority pollutant TCE (22, 23, 28, 29, 37, 47). It is highly flammable and can be harmful to human health if inhaled, ingested, or absorbed through the skin in large amounts. Chamblee, GA 30341-3717. Toluene was first isolated by Pierre-Joseph Pelletier (1788–1842) and Philippe Walter (1810–1847) in 1837. This structural difference leads to variations in their physical and chemical properties, such as Nome del prodotto : Toluene Codice del prodotto : 244511 Marca : Sigma-Aldrich N. 5. Crystals of T4moH were submerged in neat toluene for several seconds to obtain the substrate bound enzyme Toluene MSDS Section 1: Chemical Product and Company Identification Product Name: Toluene Catalog Codes: SLT2857, SLT3277 CAS#: 108-88-3 RTECS: XS5250000 TSCA: TSCA 8(b) inventory: Toluene CI#: Not available. , bond lengths, bond angles, etc. These findings suggest that environmental exposure to benzene and toluene disrupts lipid metabolism in human … May 24, 2024 · Benefits of Toluene. Toluene, C6 H5 -CH3, is a clear colorless liquid, highly flammable with a sweet, pungent aromatic odor. Individuals with different immunogenetic backgrounds have different sensitivities to toxic chemical exposure. Il toluene o metilbenzene è un derivato del benzene avente formula C 6 H 5 CH 3 in cui al posto di un atomo di idrogeno è presente un gruppo metilico. Sintesi. -S. Abstract. 957: Besley and Bottomley, 1974: Coefficents calculated by NIST from author's data. 0 µM (range, 2. [ all data ] Tsonopoulos and Ambrose, 1995 Toluene - Thermophysical Properties. , Time-resolved photodissociation of toluene ion [E o (C 6 H 5 CH 3 + Ü C 7 H 7 + + H)=2. 1Exposure data. The chemical formula of toluene can be written as C6H5CH3. May be fatal if swallowed and enters airways. The compound has attracted notoreity as the most common member of chemical food contaminants known as chloropropanols. It is also produced in the process of making gasoline and other fuels from crude oil and making coke from coal. As a volatile solvent, misuse or abuse is common, resulting in an acute toxidrome. To view TLV and Documentation, you must be logged in as an ACGIH member Huang, F. Optimized 3D Structure Images of Toluene. INDICE : 601-021-00-3 Num. Leaking underground storage tanks can contaminate the soil with toluene and other petroleum-product components. Jul 5, 2024 · Pure toluene (melting point, -95° C [-139° F]; boiling point, 110. Toluene is a liquid, which is colourless, water GHS Toluene Labels. Reasonably anticipated to be human carcinogens. nel rispetto del regolamento (CE) n. General health effects of toluene are also discussed in more limited detail. It may also cause cardiac arrhythmia. o-Xilene ≥98 %, per sintesi codice articolo: 8749 Italia (it) Pagina 4 / 21. [23] The neurotoxic effects of long-term use (in Benzene and toluene fatalities J Occup Med. Furthermore, there was a positive relationship between neurological abnormalities and a self-reported neuropsychiatric measurement (r = 0. 26471-62-5. J. Exposure to toluene occurs from breathing contaminated workplace air, in automobile exhaust, some consumer products paints, paint thinners, fingernail polish Toluene is a clear, colorless liquid with a distinctive smell. Synthetic or naturally occurring antioxidants such as butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), propyl gallate sodium L-ascorbate, and α-tocopherol have been widely used as food additives in various processed foods to prevent auto-oxidation of fatty acids. Benzene May 4, 2011 · In addition, workers who were continuously exposed to toluene had a lower mean platelet count (216 ± 41 × 10 6 /µL) than workers who were intermittently exposed (252 ± 40 × 10 6 /µL), (p = 0. A brief description of chemical properties and environmental prevalence is given, followed by a review of pharmacokinetic data. TCE is the most commonly reported groundwater contaminant, and aromatic hydrocarbon-degrading bacteria are believed to be responsible for the endogenous remediation Toluene is an organic, water-insoluble, liquid aromatic hydrocarbon consisting of a CH3 group attached to a phenyl group. Chemical, physical and thermal properties of toluene, also called methylbenzene, toluol and phenylmethane. 1°F), and hence, t oluene must be pressurized to remain liquid at higher temperatures than that. Some substance identifiers may have been claimed Jun 16, 2023 · hazard classification. sostanzialmente da un agente cancerogeno all'altro (ad esempio, 100 tumori su 1. 6°C. ; Dunbar, R. Toluene is a clear, colourless liquid with a benzene-like odour. The methyl group of toluene is a side chain in the aromatic ring structure and is oxidised to the carboxyl group in the presence of a strong oxidising agent. No changes in lung weight or histology were reported in female mice exposed to 600 mg/kg/day via gavage for 14 days, compared with controls. " CSFAN/FDA internal memorandum, cited in CDRH Risk Assessment Committee Report, " Potential carcinogenic risk from release of 2,4-TDA from the polyester polyurethane foam covering of silicone gel-filled breast implants . may cause respiratory tract, eye and skin irritation. Death can result. Toluene is made only Table 5-1 lists the facilities in each state that manufacture or process toluene, the intended use, and the range of maximum amounts of toluene that are stored on site. Authors Toluene is marketed principally as nitration and industrial grades, its purity being dependent on the specific gravity and boiling range of the product (Hoff, 1983). Toluene biotransformation leads to the generation of reactive oxygen species that cause oxidative stress and DNA damages. Gruppo 3: non classificabile come cancerogeno. 69 has been used as model compound in studies carried out to decipher the molecular mechanisms of solvent tolerance in Pseudomonas, although the effect of butanol and ethanol especially in Escherichia coli strains has become the focus of intense study due to the use of these alcohols in the bioenergy industry Apr 14, 2000 · Toluene dioxygenase and other toluene-oxidizing enzymes detoxify the suspected carcinogen and U. 0) after 90 min. 000 lavoratori esposti al cromo VI nei procedimenti di saldatura contro 4 tumori su 1. Toluene is an industrial chemical produced in high volume, that is used in blending gasoline and as a solvent. Jul 20, 2021 · Oxidation of toluene (an organic pollutant), into useful chemical products, is of great interest nowadays. As toluene is an aromatic compound, it is less susceptible to an oxidation reaction. 1907/2006 (REACH) modificato con 2020/878/UE. Technical grades (90–120°C boiling range) are less pure and may contain up to 25% benzene as well as other hydrocarbons (Clement May 10, 2024 · Ingestion: Can cause effects as described for inhalation. There are currently 2,198 facilities that produce, process, or use toluene in the United States. Toluene is used in making paints, paint thinners, fingernail polish, lacquers, adhesives, and rubber and in Toluene is a colorless liquid which has good dissolution properties. , The heat capacity of toluene from 14 deg K to 298 deg K. Subcutaneous injections of toluene (50, 500 mg/kg) or DES (2 mg/kg) were administered to male Sprague-Dawley rats for 10 days in order to lower their blood Sep 23, 2005 · Basis: Under the Guidelines for Carcinogen Risk Assessment (U. Oxidation of Toluene. View. This pale yellow crystalline solid is well known as a precursor to trinitrotoluene (TNT) but is mainly produced as a precursor to toluene diisocyanate . " Toluene has a molecular formula of C7H8, while xylene has a molecular formula of C8H10. Ingestion of toluene can lead to a swollen liver, depression of the central nervous system (CNS), congestion and hemorrhage of the lungs and necrosis of myocardial fibres. Apr 13, 1999 · VOL. 9–9. L’alcol, il benzene, la naftalina usata come antitarme negli armadi, ma anche farmaci come la ciclosporina, impiegata per impedire il rigetto in caso di trapianto anche in alcuni tipi di tumore: tutte queste sostanze hanno in comune l’appartenenza al gruppo 1 della IARC. Toluene reacts with many other chemical compounds and can be used in different chemical reactions. As the upstream crude price witnessed an upsurge due to the Russia-Ukraine conflict resulting in the price hike in the Toluene market. Toluene, aromatic hydrocarbon used extensively as starting material for the manufacture of Multiple studies of humans chronically exposed to mixtures of solvents containing toluene provide supporting evidence for toluene-mediated hearing loss, but concurrent exposure to other solvents limits the conclusions that can be drawn about toluene toxicity. Scheda dati di sicurezza. Chem. Synonyms: Aantisal 1a; Methacide; Methyl-benzene; Methylbenzol; Monomethyl benzene; Phenyl methane; Toluol; Tolu-sol. Breathing high levels of toluene during pregnancy has been shown to result in children with birth defects and to retard mental abilities and growth. When added to a tank of sulfur dichloride, the tank over pressurized and ruptured in a Toluene definition: A colorless flammable aromatic liquid, C 7 H 8 , obtained from coal tar or petroleum and used in aviation fuel and other high-octane fuels, in dyestuffs, explosives, and as a solvent for gums and lacquers. The ACGIH Threshold Limit Value (TLV) was established in 2006. Choose the actual unit of temperature: °C Toluene exposure may cause liver and kidney damage. 1: kJ/mol: Review: Roux, Temprado, et al. The output density is given as kg/m 3, lb/ft 3, lb/gal (US liq) and sl/ft 3 . Specific weight is given as N/m 3 and lb f / ft 3. Toluene prices witnessed an upward trajectory in the first quarter of 2022. Only certain types of facilities were Mar 20, 2023 · LD means lethal dose. The uses of benzene as a solvent are now restricted in Temperature (K) A B C Reference Comment; 273. ) at the lowest energy World Health Organization Toluene is a clear, colorless liquid with a distinctive smell. Abstr. 3 days ago · Reactions of Toluene. LD50 is the amount of substance that, when given as a single dose, results in the death of half of the test animals. Toluene Revision Date 25-Dec-2021 TDG UN-No UN1294 Proper Shipping Name TOLUENE Hazard Class 3 Packing Group II IATA UN-No UN1294 Proper Shipping Name TOLUENE Hazard Class 3 Packing Group II IMDG/IMO UN-No UN1294 Proper Shipping Name TOLUENE Hazard Class 3 Packing Group II 15. Manganese oxide-based (Mn-based) catalysts have received increased attention due to their high catalytic performance, good physicochemical characteristic, availability in various crystal structures and morphologies, and Immediate effects include narcosis, fatigue, sleepiness, headache, nausea. Chronic low-level occupational or industrial exposure to toluene can cause toxicity. 2 Usi identificati pertinenti della sostanza o della miscela e usi sconsigliati Usi identificati : Chimici di laboratorio, Produzione di sostanze chimiche Nov 28, 2023 · Toluene is a clear, flammable, aromatic hydrocarbon liquid with a smell similar to benzene. 23679: 1426. It is a colorless, water-insoluble liquid with the odor associated with paint thinners. A4 —Not Classifiable as a Human Carcinogen. (79654) Toluene: Highly flammable liquid and vapor. Molecular formula: C 7 H 8. Causes skin irritation. Huang, F. Toluene is a clear, colorless liquid which becomes a vapor when exposed to air at room temperature. The TLV for toluene was established to protect Notice: Except where noted, spectra from this collection were measured on dispersive instruments, often in carefully selected solvents, and hence may differ in detail from measurements on FTIR instruments or in other chemical environments. Toluene is a naturally occurring compound derived primarily from petroleum or petrochemical processes. 3 Raccomandazioni per gli addetti all'estinzione degli incendi In caso di incendio e/o esplosione non respirare i fumi. This classification does not indicate the level of risk associated with exposure. A series of time-dependent IR spectra of the reaction over the sample was sequentially recorded with a temperature interval of 10 °C from 50 to 400 °C in O 2 and Toluene will readily evaporate into the air or be degraded by microorganisms in surface waters. Jul 5, 2024 · Group 1: Carcinogenic to humans: 129 agents: Group 2A: Probably carcinogenic to humans 96 agents: Group 2B: Possibly carcinogenic to humans: 321 agents: Group 3 Apr 7, 2024 · Efficient sensors for toluene detecting are urgently needed to meet people’s growing demands for both environment and personal health. Summary of Data Reported and Evaluation. C. Usi. Il toluene è scarsamente solubile in acqua mentre è solubile in etanolo, etere etilico, benzene e cloroformio. Un agente carcinogeno o cancerogeno, (rispettivamente dal greco Καρκίνος o dal latino Cancer, granchio, col suffissoide -geno, dal greco Γένεσις, genesi, che genera cancro) è un fattore chimico, fisico o biologico (molecola o miscela chimica, radiazione, agente virale, batterico, fungino, animale, condizione di esposizione) in grado di causare tumori o favorirne l'insorgenza e Jan 1, 2013 · Toluene, with a logP ow of 2. Oct 14, 2022 · Benzene and toluene metabolites were significantly and positively associated with hypertriglyceridemia. IUPAC Standard InChIKey: YXFVVABEGXRONW-UHFFFAOYSA-N Copy CAS Registry Number: 108-88-3 Chemical structure: This structure is also available as a 2d Mol file or as a computed 3d SD file Eating foods or drinking fluids contaminated with high levels of benzene can cause vomiting, stomach irritation, dizziness, sleepiness, convulsions, and rapid heart rate. 6 °C (231. 89: 4. 448-45. Effects of Long-Term (Chronic) Exposure: Can cause dry, red, cracked skin (dermatitis) following skin contact. This volume presents an evaluation of the carcinogenicity of benzene, updating the most recent evaluation provided in Volume 100F of the IARC Monographs. Soc. 000 laoratori esposti all’ossido di etilene). Using the geometry optimization results, high-quality images of 3D molecular structures have been prepared for toluene in 3 different models, namely, stick, ball & stick, and space-filling, which provide not only the basic structure information but also a physically meaningful configuration (e. Suspects of damaging the unborn child by inhalation. Improves Fuel Efficiency: When used as a fuel additive, toluene increases the octane rating of gasoline, helping engines run more efficiently. May cause damage to the central nervous system by inhalation. Gruppo 2B: possibilmente cancerogeno. Most inhalants are central nervous system depressants that are addicting physically and psychologically. LD50 of toluene for oral route is LD50>5000 mg/kg, for dermal route is LD50> 5000 mg/kg, and for inhalation route LC50> OR = 20mg/L. In extreme cases, inhaling or swallowing very high levels of benzene can be deadly. 829) CAS No. Toluene is also used in the production of other chemicals such as benzene, xylenes, and TNT. Versatile Chemical Precursor: Toluene serves benzene volume 120 benzene iarc monographs on the evaluation of carcinogenic risks to humans This Public Health Statement summarizes the Agency for Toxic Substances and Disease Registry’s (ATSDR) findings on toluene, including chemical characteristics, exposure risks, possible health effects from exposure, and ways to limit exposure. Its chemical formula is that of methylbenzene, C 6 H 5 CH 3. A. No respiratory effects were reported in mice or rats after oral exposure to toluene at dosage levels up to 2,500 mg/kg/day for 13 weeks or 590 mg/kg/day for 6 months. This infographic presents the categories used by the IARC Monographs on the Identification of Carcinogenic Hazards to Humans to classify a substance according to the level of certainty that the substance can cause cancer. The hallmarks of toluene intoxication are distal renal tubular acidosis type 1 (RTA-1), classically described as hyperchloremic with a normal anion-gap, as well as hypokalemia and muscle paralysis . The ‘Substance identity’ section is calculated from substance identification information from all ECHA databases. Asia Pacific. For example, using microPET, [ 84] it has been shown that acute and repeated toluene exposure markedly reduces metabolic function in rat brain. It is a good solvent (a substance that can dissolve other substances). Toluene occurs naturally in crude oil and in the tolú tree. , 1929, 51, 2738. Catalytic efficiencies of MnMoO4 nanomaterials were evaluated by direct Overview. General health effects include lethality, growth, morbidity, liver and kidney damage and miscellaneous effects. ], Int. The toluene molecular formula is C 7 H 8. May cause drowsiness or dizziness. Gli agenti e le circostanze esposte in questo elenco sono state classificate come gruppo 1 dall' Agenzia internazionale per la ricerca sul cancro (IARC TOLUENE reacts vigorously with allyl chloride or other alkyl halides even at -70°C in the presence of ethyl aluminum dichloride or ethyl aluminum sesquichloride. However, urinary ttMA and BMA levels were negatively associated with high LDL-C levels. Toluene and xylene. CAS : 108-88-3 1. It is a component of gasoline, vehicle exhaust, industrial emissions, and tobacco smoke, and was used historically as a solvent in industry and consumer products. Toluene vapor has a sharp or sweet odor, which is a sign of exposure. The International Agency for Research on Cancer (IARC) is pleased to announce that the IARC Monographs volume on benzene is now available online. Toluene occurs naturally in crude oil and in the tolu tree. Nov 21, 2023 · Toluene Formula. 3-MCPD ( 3-monochloropropane-1,2-diol or 3-chloropropane-1,2-diol) is an organic chemical compound with the formula HOCH 2 CH (OH)CH 2 Cl. 1971 May;13(5):259-61. It has a density 0. Toluene affects the central nervous system, eyes, skin, respiratory system, liver, kidneys. Metal oxide semiconductor (MOS)-based sensors have become brilliant candidates for the detection of toluene because of their superior performance over gas sensing. However, gas sensors based on pure MOS have certain limitations in selectivity, operating Oct 26, 2017 · Benzene, an aromatic hydrocarbon, is a ubiquitous air pollutant, arising mostly from anthropogenic sources, notably combustion. For more information, contact: Agency for Toxic Substances and Disease Registry. Chemical properties. 018). Reagent-grade toluene is available with a purity of greater than 99% (Aldrich Chemical Co. Toluene is readily broken down to other chemicals by microorganisms in the soil. - Non ’è alun in entio a minimizzare l'esposizione al di sotto di un VLEP in olante Oct 14, 2022 · Toluene is a gasoline additive that can be used to improve octane ratings for fuel used in race cars and other automobiles. 35-0. The oxidation of toluene forms benzaldehyde which can Dec 21, 2021 · Administration of 1,4-dioxane in drinking water caused benign or malignant liver tumors (hepatocellular adenoma or carcinoma) in mice of both sexes, female rats, and male guinea pigs. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. Toluene is a common component in gasoline, glues, and paint products. © IARC 1965-2024 — All Rights Reserved "Upper bound risk for 2,4 toluene diamine (TDA) and dibutyl diacetate (DBTA) in FAPs 8B3370 and 8B3371 quantitative risk. It is a mono-substituted benzene derivative, consisting of a methyl group Apr 11, 2016 · Chimicamo. Reazioni. 2,4-Dinitrotoluene ( DNT) or dinitro is an organic compound with the formula C 7 H 6 N 2 O 4. The higher the octane number or rating, the greater the fuel’s resistance to knocking or pinging during combustion. Modeling uncertainties give considerable latitude in the assignment of kinetic parameters. It also caused cancer of the nasal cavity (squamous-cell carcinoma) in rats of both sexes and gallbladder cancer (carcinoma) in male guinea pigs ( IARC 1976; NCI . Temperature. Mar 25, 2015 · toluene 1. 6° C [231. There is evidence that exposure to toluene at work is Toluene is toxic. Incompatible with strong oxidizing agents. Of the inhaled toluene, 51% (range, 48–56) was absorbed, leading to a steady-state blood concentration of 5. Here, we report MnMoO4 nanomaterials (CH1–CH2), synthesized through a very facile solvothermal approach. Gruppo 1: cancerogeno. , J. vapor may cause flash fire. The toluene formula shows that its molecule is composed of a total of seven carbon atoms and eight hydrogen atoms. Explosions have been reported [NFPA 491M 1991]. ATSDR can also tell you the location of occupational and environmental health clinics. 1 ± 1. Regulatory information United States of America Inventory Dec 21, 2021 · CAS No. Toluene has a low acute toxicity. It is a colorless liquid. Occupational exposure to toluene is extensive and occurs in its production and during the Dec 19, 2018 · IARC Monographs Volume 120: Benzene. Apr 20, 2023 · Toluene is a member of the aromatic hydrocarbon family, which means it contains a benzene ring in its molecular structure. Isomers also known as toluene-2,4-diisocyanate and toluene-2,6-diisocyanate. Chemical structure: TLV–TWA, 20 ppm. Toluene undergoes alkylation in the presence of modified ZSM (Zeolite Socony Mobil)-5-class zeolite catalysts to form p-xylene with high selectivity. Presenta sei atomi di carbonio ibridato sp 2 25 avenue Tony Garnier CS 90627 69366 LYON CEDEX 07 France 33 (0)4 72 73 84 85 . Long-term toluene exposure is often associated with effects such as: psychoorganic syndrome; [24] visual evoked potential (VEP) abnormality; [24] toxic polyneuropathy, cerebellar, cognitive, and pyramidal dysfunctions; [23] [24] optic atrophy; hearing disorders [25] [26] and brain lesions. [2] [3] It is also used in nail products to suspend the color and form a smooth finish across the nail. Phone: 1-800-CDC-INFO 888-232-6348 (TTY) Email: Contact CDC-INFO. Effective Solvent: Toluene dissolves a wide range of organic compounds, making it valuable in producing paints, coatings, and adhesives. Long-term exposure to the liquid can cause neurological damage. Phase diagram included. ChemicalBook Provide Toluene(108-88-3) 13C NMR,IR2,MS,IR3,IR,1H NMR,Raman,ESR,13C NMR,Spectrum While only limited evidence of benzene carcinogenicity in experimental animals exists, the recent findings of the National Toxicology Program (NTP, 1984) in the U. 1° F]) is a colourless, flammable, toxic liquid, insoluble in water but soluble in all common organic solvents. Toluene consists of a single methyl group attached to a benzene ring, whereas xylene has two methyl groups attached to different positions on the benzene ring. 11 eV; cited data derived using evaluated IP for toluene. [1] It is suspected to be carcinogenic in humans. L’agenzia dell’OMS, con sede a Lione, in base ai risultati degli Aug 18, 2015 · Toluene is metabolized by cytochrome p-450 into benzoic acid and hippuric acid, these are excreted by the kidney [8, 9]. S. identification product name: toluene chemical family: aromatic hydrocarbon cas # 108-88-3 synonyms: toluene, toluol, methylbenzene 2. It is produced in the process of making gasoline and other fuels from crude oil and in making coke from coal. Office of Innovation and Analytics, Toxicology Section. Toluene boiling point at atmospheric pressure is 110. However, efficient conversion of toluene under mild and sustainable conditions is a thought-provoking task. aspiration hazard. Carl Roth - International | Homepage Mar 27, 2017 · Crystals appeared within two days, and grew to a maximum size of 200 × 100 × 200 μm. 4770 Buford Highway. The data listed in Table 5-1 are derived from the Toxics Release Inventory (TRI15 2016). Toluene is less dense than water and is slightly soluble in water . Synonym: Toluol, Tolu-Sol; Methylbenzene; Methacide; Phenylmethane; Methylbenzol Chemical Name: Toluene Chemical Formula: C6-H5-CH3 or C7-H8 Toluene undergoes alkylation in the presence of modified ZSM (Zeolite Socony Mobil)-5-class zeolite catalysts to form p-xylene with high selectivity. Am. the entropy and the free energy of formation. Gruppo 2A: probabilmente cancerogeno. Toluene in surface soils rapidly evaporates into the air. In addition, many naturally occurring antioxidants are Toluene is a clear, colourless liquid with a distinctive smell. 1. Henceforth, the cost of Toluene in the USA settled at USD 1225 per MT in March 2022. may be harmful if swallowed. IUPAC Standard InChIKey: YXFVVABEGXRONW-UHFFFAOYSA-N Copy CAS Registry Number: 108-88-3 Chemical structure: This structure is also available as a 2d Mol file or as a computed 3d SD file Jan 11, 2024 · Toluene is a simple benzene derivative also known as methylbenzene, phenylmethane, or toluol. Name: Methylbenzene. Products that may contain toluene-such as paint, metal cleaners and Toluene, found naturally in crude oil and in the tolu tree, is added to gasoline [2] and is used in the making of many products including paint thinners, adhesives, rubber and hair dyes. We are told blandly by the US Department of Health that ‘ingestion of approximately 60 millilitres of toluene proved fatal for a white male mental patient,’ and like many organic solvents, because of its impact on the central nervous system where it alters neurotransmitter binding, toluene can cause unfortunate reactions Jan 1, 2024 · Toluene poisoning manifests as distal renal tubular acidosis type 1 (RTA-1), which is commonly characterized as hyperchloremic with a normal anion-gap, hypokalemia, and muscular paralysis. Jun 1, 2023 · Toluene gas was bubbled into the reactor with oxygen flow (30 mL/min), and the corresponding sample spectrum was recorded until the catalyst was saturated with adsorbed toluene. May cause genetic defects. NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 500 ppm. After the identification of some of toluene’s molecular actions, several research groups studied metabolic and neurochemical changes associated with toluene exposure. May be drawn into the lungs if swallowed or vomited, causing severe lung damage. , 2008: There are sufficient high-quality literature values to make a good evaluation with a high degree of confidence. Toluene is typically used in a mixture with other solvents and chemicals such as paint pigments. Toluene is used in these applications because it is dense and contains significant energy per unit of Classificazione IARC delle sostanze cancerogene. g. , 1988). : 108-88-3 Chem. 87 g/cm³ at room temperature and pressure and a boiling point of 110. While the Occupational Safety and Health Administration CAS number: 108-88-3. National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 100 ppm (375 mg/m 3) 10-hour TWA; 150 ppm (560 mg/m 3) STEL. and Maltoni et al. : 71 (1999) (p. First listed in the Fourth Annual Report on Carcinogens (1985) Also known as TDI; 1,3-diisocyanatomethyl benzene; isocyanic acid, methyl- m -phenylene ester; or tolylene diisocyanate. hazards identification emergency overview flammable liquid and vapor. Available in various quantities and reagent grades, it is used as a precursor to benzene, a solvent, an octane booster in gasoline, etc. Dec 17, 2019 · It is necessary to control the emissions of toluene, which is hazardous to both human health and the atmosphere environment and has been classified as a priority pollutant. The second, rapid half-life time of elimination ( t½β) was 40 min (range, 25–71 min). When doped on graphene, it acts as an electron donor leading to alteration in graphene electrical properties due to electrochemical interaction. Toluene. It is also called methylbenzene, indicating that a methyl group has been added to one of benzene’s carbon atoms. Toluene easily evaporates and forms volatile explosive vapors. Toluene (), also known as toluol (), is a substituted aromatic hydrocarbon with the chemical formula C6H5CH3, often abbreviated as PhCH3, where Ph stands for phenyl group. Three of the women were rapid hydroxylators and three were slow hydroxylators. REACH : 01-2119471310-51-XXXX N. Toluene is used in making paints, paint This Public Health Statement summarizes the Agency for Toxic Substances and Disease Registry’s (ATSDR) findings on toluene diisocyanate (TDI) and methylenediphenyl diisocyanate (MDI), including chemical characteristics, exposure risks, possible health effects from exposure, and ways to limit exposure. (1985) strongly indicate that benzene is an experimental carcinogen. EPA, 2005), there is inadequate information to assess the carcinogenic potential of toluene because studies of humans chronically exposed to toluene are inconclusive, toluene was not carcinogenic in adequate inhalation cancer bioassays of rats and mice exposed for life (CIIT, 1980 NTP, 1990 Huff, 2003), and increased incidences Toluene will readily evaporate into the air or be degraded by microorganisms in surface waters. Jun 26, 2024 · Inhaling, or huffing, chemicals such as gasoline, paint thinner and adhesives containing toluene and benzene produces a high similar to alcohol intoxication — loss of inhibition, slurred speech, euphoria, dizziness and disorientation. tu jy we lh vw lx rv bn pp ft